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Sunday, August 2, 2020 | History

2 edition of Triaxial compaction of pharmaceutical powders found in the catalog.

Triaxial compaction of pharmaceutical powders

H. Asghar

Triaxial compaction of pharmaceutical powders

by H. Asghar

  • 325 Want to read
  • 35 Currently reading

Published by UMIST in Manchester .
Written in English


Edition Notes

StatementSupervised by: Al-Hassani, S.T.S..
ContributionsAl-Hassani, S. T. S., Supervisor., Mechanical Engineering (A.M.).
ID Numbers
Open LibraryOL20807332M

Modelling of Powder Die Compaction: Manufacture of components from powders frequently requires a compaction step. This is widely used in the powder metallurgy, ceramic, hardmetal, magnet, pharmaceutical, refractory and other sectors to make anything from complex gears for cars to pills to dishwasher tablets. Development of the tooling to manufacture a component can be a long process . DOI link for Pharmaceutical Powder ComPattion Technology. Pharmaceutical Powder ComPattion Technology book. Edited By Goran Alderborn, Christer Nystrom. Edition 1st Edition. First Published eBook Published 26 September Pub. location Boca Raton. Imprint CRC Press.

Particle dimensions -- Mechanical properties -- Granule properties -- Modeling the compression behavior of particle assemblies from the mechanical properties of individual particles -- V. Compaction properties of excipients and powder mixtures -- Materials for direct compaction -- Compaction properties of binary mixtures -- Book Description. This unique reference examines the modern pharmaceutical compacting techniques used to form tablets out of powders-describing the physical structure of pharmaceutical compacts, the bonding phenomena that occur during powder compaction, and the compression mechanisms of pharmaceutical particles.

The approach is to use a combination of experimental compaction simulation and discrete element models to parameterise appropriate constitutive equations (e.g. the density-dependent Drucker-Prager cap model [1]) for the powders, which can then be used in finite element simulations of the tablet compaction process.   Get ebook: $ Pharmaceutical Powder Compaction Technology Pharmacology Compaction of powder constituents―both active ingredient and excipients―is examined to ensure consistent and reproducible disintegration and dispersion profiles. Revised to reflect.


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Triaxial compaction of pharmaceutical powders by H. Asghar Download PDF EPUB FB2

Compaction of powder constituents—both active ingredient and excipients—is examined to ensure consistent and reproducible disintegration and dispersion profiles.

Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and.

The mechanical behaviour of pharmaceutical powders during compaction is analysed using Finite Element Methods (FEM), in which the powder is modelled as an elastic–plastic continuum material. Compaction of powder constituents-both active ingredient and excipients-is examined to ensure consistent and reproducible disintegration and dispersion profiles.

Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists,Cited by: Powder Metallurgy Processing: New Techniques and Analyses covers the application of advanced analytical techniques in metallurgy, mechanics, and economics to the fundamentals of powder fabrication processes.

The book discusses powder production by gas and water atomization of liquid metals; the triaxial stress state compaction of powders; and. The compressed tablet is the most common pharmaceutical dosage form on the planet, and consequently tablet compaction is the second most common unit operation in pharmaceutical product process engineering after dry powder blending.

This chapter provides insights into the technical detail of compaction and a useful guide to process design. The compaction properties of pharmaceutical powders are characterised by their compressibility and compactibility.

While compressibility is the ability of the powder to deform under pressure. 2. FEM for powder compaction. Finite element methods (FEM) have been widely used for modelling the compaction of metallic and ceramic powders,, and have recently been used for analysing pharmaceutical powder compaction.

In FEM, powders are modelled as continuum media and the compaction behaviour is analysed by solving boundary.

A high pressure triaxial testing facility has been developed to investigate the compaction behaviour of powders. The facility can test cylindrical powder specimens up to hydrostatic pressures of MPa and superimposed axial loads up to MPa, which are applied using two independent servo systems controlled by a computer.

we will examine two solid dosage forms, powders and granules. T I. POWDERS Powder is a mixture of finely divided drugs and/or chemicals in dry form. Powders can be used internally and externally (e.g., external applications to the skin). Dry powders, however, can be taken orally by some patients.

PHARMACEUTICAL POWDERS Historically, powders represent one of the' oldest dosage forms. A pharmaceutical powder is solid dosage form which contains mixture of finely divided drugs or chemicals in a dry form meant for internal or external use.

It is a preparation in which drug is blended with other powdered substances and used for internal or. Corpus ID: Experimental studies and modeling of the roller compaction of pharmaceutical powders @inproceedings{CunninghamExperimentalSA, title={Experimental studies and modeling of the roller compaction of pharmaceutical powders}, author={John C.

Cunningham}, year={} }. Abstract. Stress-strain curves for a compacting powder were obtained from tests in a specially developed high-pressure triaxial apparatus. A powder-wall shear apparatus was used to determine the stresses at a wall as a function of the powder-wall displacement.

Buy Pharmaceutical Powder Compaction Technology Books online at best prices in India by Metin Celik,Metin Çelik from Buy Pharmaceutical Powder Compaction Technology online of India’s Largest Online Book Store, Only Genuine Products.

Lowest price and Replacement Guarantee. Cash On Delivery Available. The compaction behavior of steel powders, hard metals, and ceramic powders have been investigated using a newly developed high pressure triaxial testing facility. Results from isostatic compaction, simulated closed die compaction, and compaction along different radial loading paths in stress space are presented for six commercial powders.

Medical Books Free. Pharmacology. Nov 24 Compaction of powder constituents―both active ingredient and excipients―is examined to ensure consistent and reproducible disintegration and dispersion profiles.

Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction. To study the behaviour of these powders during their compaction along different loading paths, a novel triaxial device has been designed and installed on a six-actuator triaxial testing machine.

The results obtained for hydrostatic loading were favourably. In dry granulation, the powder blend is compacted by applying a force onto the powder, which in general causes a considerable size enlargement. Principally there are two methods to obtain the compacts when using dry granulation: slugging and roller compaction.

Slugging If a tablet press is used for the compaction process, the term slugging is used. Revised to reflect modern pharmaceutical compacting techniques, this second edition of Pharmaceutical Powder Compaction Technology guides pharmaceutical engineers, formulation scientists, and product development and quality assurance personnel through the compaction formulation process and application.

Cubical triaxial tester Pharmaceutical powder Pharmaceutical tablets are formed using formulations consisting of ingredients such as filler, binder, discrete and continuum approach to model the powder compaction Powder Technology () 26–34 ⁎ Corresponding author.

breakage behaviour of tablets after compaction. In order to simulate powder compaction and post compaction behaviour an appropriate constitutive model is required.

To calibrate the constitutive model (e.g. a Drucker-Prager Cap model) a series of experiments were carried out including closed die compaction, uniaxial and diametrical compression. A powder is a dry, bulk solid composed of many very fine particles that may flow freely when shaken or tilted.

Powders are a special sub-class of granular materials, although the terms powder and granular are sometimes used to distinguish separate classes of material. In particular, powders refer to those granular materials that have the finer grain sizes, and that therefore have a greater.

Pharmaceutical Powder Compaction Technology by Metin Celik,available at Book Depository with free delivery worldwide.Genre/Form: Electronic books: Additional Physical Format: Print version: Pharmaceutical powder compaction technology. New York: Marcel Dekker, ©